CaltechAUTHORS
Published April 2013 | Version Published
Journal Article Open

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Creators

  • 1. ROR icon Wellcome Centre for Cell Biology
  • 2. ROR icon University of Pennsylvania
  • 3. ROR icon University of North Carolina at Chapel Hill
  • 4. ROR icon Baylor College of Medicine
  • 5. ROR icon University of Nottingham
  • 6. ROR icon Massachusetts Institute of Technology
  • 7. ROR icon Murdoch Children's Research Institute
  • 8. ROR icon Royal Children's Hospital
  • 9. ROR icon Colorado State University
  • 10. ROR icon University of California, San Diego
  • 11. ROR icon Leibniz Institute on Aging – Fritz Lipmann Institute
  • 12. ROR icon DKFZ-ZMBH Alliance
  • 13. ROR icon University of Massachusetts Amherst
  • 14. ROR icon University of Virginia
  • 15. ROR icon National Institute of Genetics
  • 16. ROR icon University of Porto
  • 17. ROR icon Institute of Molecular Biotechnology
  • 18. ROR icon University of Cambridge
  • 19. ROR icon Oklahoma Medical Research Foundation
  • 20. ROR icon Harvard University
  • 21. ROR icon Max Planck Institute of Immunobiology and Epigenetics
  • 22. ROR icon Japanese Foundation For Cancer Research
  • 23. ROR icon Lawrence Berkeley National Laboratory
  • 24. ROR icon University Medical Center Utrecht
  • 25. ROR icon Spanish National Cancer Research Centre
  • 26. ROR icon Institute for Research in Immunology and Cancer
  • 27. ROR icon Sanford Burnham Prebys Medical Discovery Institute
  • 28. ROR icon Kazusa DNA Research Institute
  • 29. ROR icon University of Warwick
  • 30. ROR icon University of Connecticut
  • 31. ROR icon University of Geneva
  • 32. ROR icon Max Planck Institute of Molecular Physiology
  • 33. ROR icon Duke University
  • 34. ROR icon Stanford University
  • 35. ROR icon National University of Ireland, Galway
  • 36. ROR icon University of Dundee
  • 37. ROR icon Indiana University Bloomington
  • 38. ROR icon Icahn School of Medicine at Mount Sinai
  • 39. ROR icon Research Institute of Molecular Pathology
  • 40. ROR icon University of Washington
  • 41. ROR icon Okinawa Institute of Science and Technology
  • 42. ROR icon Fox Chase Cancer Center
  • 43. ROR icon Nagoya University

Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

Additional Information

© The Author(s) 2013. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Received: 15 March 2013 / Revised: 17 March 2013 / Accepted: 17 March 2013 / Published online: 12 April 2013. WCE and RCA are Principal Reseach Fellows of the Wellcome Trust [grant numbers 073915 and 095021, respectively]. The Wellcome Trust Centre for Cell Biology is supported by core grant numbers 077707 and 092076. BEB is funded by NIH R01-GM082989, a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund and a Rita Allen Foundation Scholar Award. KB is funded by grant R37 GM32238. IMC is funded by NIH grant GM088313. DWC is an Investigator of the Ludwig Institute, whose centromere work is supported by NIH grant GM074150. GPC thanks the National Science Foundation (MCB-1121563) for support. JGD is supported by NIH R01GM088371. TF is supported by the Cabinet Office, Government of Japan, through its 'Funding Program for Next Generation World-Leading Researchers'(LS122). RG is funded by an EMBO Installation Grant. DWG is funded by the European Community's Seventh Framework Programme FP7/2007-2013 under grant agreements no. 241548 (MitoSys) and no. 258068 (Systems Microscopy) and from an ERC Starting Grant (no. 281198). DMG is supported by Cancer Research UK and the MRC. GJG is funded by NIH/NIGMS R01-50412, the Oklahoma Center for Advancement of Science and Technology and the McCasland Foundation. PH is funded by Seventh Framework Programme grant BioSynCen from the European Research Council. TH is funded by Research Grants from the Japanese Society for the Promotion of Science (JSPS) and the Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT). LETJ is funded by FCT grants BIA-BCM/100557/2008, BIAPRO/100537/2008 and an EMBO installation grant. GK is funded by NIH grant 5R01GM61169, GJPLK is supported by grants from the ERC (KINSIGN) and the Netherlands Organisation for Scientific Research (NWO-Vici-016.130.661). MAL is funded by NIH grant GM083988. SML is supported by grants from the Dutch Cancer Society (UU2009-4311, UU2011-5134) and the Netherlands Organisation for Scientific Research (NWO-Vici-91812610). AL is supported by the Spanish Ministry of Economy (grants CSD2007-015 and SAF2010-25157) and the EU (Marie Curie ITN "Nucleosome 4D"). HM is funded by grants PTDC/SAU-GMG/099704/2008 and PTDC/SAU-ONC/112917/2009 from FCT (COMPETE-FEDER), the Human Frontier Science Program and the 7th framework program grant PRECISE from the European Research Council. ADM is funded by BBSRC grant (BB/I021353/1). RLM is funded by NIH grant R01GM088716. HM is supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and the Kazusa DNA Research Institute Foundation. PSM is supported by a grant from the CCSRI (700824). BGM is funded by NSF award number 1024973. PM is funded by the Swiss National Foundation, University of Geneva and the Foundation Louis-Jeantet. RJO is supported by the NSF. EDS is funded by NIH grant R37GM024364. AFS is funded by NIH grant R01GM074728. PTS is funded by NIH grant number-R01 GM063045. BS is funded by NIH R01 GM098500 and March of Dimes 6-FY10-294. KFS is funded by Science Foundation Ireland grant 12/IA/1370. CES is funded by grants from the Fundação para Ciência e Tecnologia of Portugal, COMPETE and ON2. JRS is funded by BBSRC grant BB/H013024. CEW is funded by NIH grant GM059618. LW is funded by NIH grant GM69429. TY is funded by NIH grant GM083988, Core Grant CA06927, and an appropriation from the Commonwealth of Pennsylvania.

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Additional details

Identifiers

PMCID
PMC3627038
Eprint ID
105878
Resolver ID
CaltechAUTHORS:20201007-123358388

Funding

Wellcome Trust
073915
Wellcome Trust
095021
Wellcome Trust
077707
Wellcome Trust
092076
NIH
R01-GM082989
Burroughs Wellcome Fund
Rita Allen Foundation
NIH
R37 GM32238
NIH
GM088313
Ludwig Institute
NIH
GM074150
NSF
MCB-1121563
NIH
R01GM088371
Cabinet Office, Government of Japan
LS122
European Molecular Biology Organization (EMBO)
European Research Council (ERC)
241548
European Research Council (ERC)
258068
European Research Council (ERC)
281198
Cancer Research UK
Medical Research Council (UK)
NIH
R01-50412
Oklahoma Center for Advancement of Science and Technology
McCasland Foundation
Japan Society for the Promotion of Science (JSPS)
Ministry of Education, Culture, Sports, Science and Technology (MEXT)
Fundação para a Ciência e a Tecnologia (FCT)
BIA-BCM/100557/2008
Fundação para a Ciência e a Tecnologia (FCT)
BIAPRO/100537/2008
NIH
5R01GM61169
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)
NWO-Vici-016.130.661
NIH
GM083988
Dutch Cancer Society
UU2009-4311
Dutch Cancer Society
UU2011-5134
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)
NWO-Vici-91812610
Ministerio de Economía, Industria y Competitividad (MINECO)
CSD2007-015
Ministerio de Economía, Industria y Competitividad (MINECO)
SAF2010-25157
Marie Curie Fellowship
Fundação para a Ciência e a Tecnologia (FCT)
PTDC/SAU-GMG/099704/2008
Fundação para a Ciência e a Tecnologia (FCT)
PTDC/SAU-ONC/112917/2009
Fondo Europeo de Desarrollo Regional (FEDER)
Human Frontier Science Program
Biotechnology and Biological Sciences Research Council (BBSRC)
BB/I021353/1
NIH
R01GM088716
Kazusa DNA Research Institute Foundation
Canadian Cancer Society Research Institute
700824
NSF
MCB-1024973
Swiss National Science Foundation (SNSF)
University of Geneva
Foundation Louis-Jeantet
NIH
R37GM024364
NIH
R01GM074728
NIH
R01 GM063045
NIH
R01 GM098500
March of Dimes
6-FY10-294
Science Foundation, Ireland
12/IA/1370
Biotechnology and Biological Sciences Research Council (BBSRC)
BB/H013024
NIH
GM059618
NIH
GM69429
NIH
GM083988
NIH
CA06927
Commonwealth of Pennsylvania
Fundação para a Ciência e a Tecnologia (FCT)
COMPETE
Fundação para a Ciência e a Tecnologia (FCT)
ON2

Dates

Created
2020-10-08
Created from EPrint's datestamp field
Updated
2023-03-16
Created from EPrint's last_modified field