CaltechAUTHORS
Published August 2023 | Version Supplemental Material
Journal Article Open

The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery

Creators

  • 1. ROR icon University of Maryland, College Park
  • 2. ROR icon University of California, Davis
  • 3. ROR icon Pennsylvania State University
  • 4. ROR icon University of Notre Dame
  • 5. ROR icon University of California, Berkeley
  • 6. ROR icon University of Washington
  • 7. ROR icon Emory University
  • 8. ROR icon University of Western Australia
  • 9. ROR icon California Institute of Technology
  • 10. ROR icon Hospital Clínic de Barcelona
  • 11. ROR icon University of Barcelona

Abstract

Fear and anxiety play a central role in mammalian life, and there is considerable interest in clarifying their nature, identifying their biological underpinnings, and determining their consequences for health and disease. Here we provide a roundtable discussion on the nature and biological bases of fear- and anxiety-related states, traits, and disorders. The discussants include scientists familiar with a wide variety of populations and a broad spectrum of techniques. The goal of the roundtable was to take stock of the state of the science and provide a roadmap to the next generation of fear and anxiety research. Much of the discussion centered on the key challenges facing the field, the most fruitful avenues for future research, and emerging opportunities for accelerating discovery, with implications for scientists, funders, and other stakeholders. Understanding fear and anxiety is a matter of practical importance. Anxiety disorders are a leading burden on public health and existing treatments are far from curative, underscoring the urgency of developing a deeper understanding of the factors governing threat-related emotions.

Additional Information

© 2023 Elsevier Ltd. Authors acknowledge assistance and critical feedback from the discussants, K. DeYoung, L. Friedman, and J. Smith. This work was supported by the California National Primate Center; National Institutes of Health (AA030042, MH131264, MH121409, MH121735, MH128336, MH129851, OD011107, MH118218, MH109692, MH114974); Pennsylvania State University; University of California, Davis; and University of Maryland. Authors declare no conflicts of interest. Author contributions: A.J.S. envisioned the virtual panel discussion. A.J.S. formulated the discussion prompts with guidance from M.A.F. and A.S.F. E.B.-M., K.A.B., L.A.C., A.S.F., D.K., A.S.C., J.J.K., P.A.K., C.M, D.M., and K.N.-G. responded to the discussion prompts. A.J.S. and L.A.C. reviewed and edited the responses. S.E.G. and A.J.S. wrote the remaining sections of the paper. M.A.F. and A.J.S. coordinated editorial communications. All authors contributed to reviewing and revising the paper and approved the final version.

Attached Files

Supplemental Material - 1-s2.0-S0149763423002063-mmc1.docx

Files

Files (2.2 MB)

Name Size
md5:660177644affd7015a138956e6f195d4
2.2 MB Download

Additional details

Identifiers

PMCID
PMC10330657
Eprint ID
122174
Resolver ID
CaltechAUTHORS:20230706-731611100.6

Funding

NIH
AA030042
NIH
MH131264
NIH
MH121409
NIH
MH121735
NIH
MH128336
NIH
MH129851
NIH
OD011107
NIH
MH118218
NIH
MH109692
NIH
MH114974
Pennsylvania State University
University of California, Davis
University of Maryland
California National Primate Center

Dates

Created
2023-08-13
Created from EPrint's datestamp field
Updated
2023-08-14
Created from EPrint's last_modified field