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Published March 4, 2019 | Version Published
Book Section - Chapter Open

Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application

Creators

  • 1. ROR icon Singapore Bioimaging Consortium
  • 2. ROR icon Pohang University of Science and Technology
  • 3. ROR icon California Institute of Technology
  • 4. ROR icon Singapore Immunology Network

Contributors

Abstract

The hemodynamics and oxygen saturation status of vascular are very important biomarkers for disease, such as brain glioma tumor and ischemia-reperfusion ulcer. Therefore, a high spatial resolution imaging tool for vascular imaging is demanded. Conventional optical imaging modalities, including confocal microscopy and two-photon microscopy, require external contrast agent to image blood vessels and are not sensitive to oxygen saturation. The development of photoacoustic microscopy provides a contrast-free, high-spatial resolution and functional vascular imaging tool. It's gaining more and more popularity in biomedical research. In this paper, we introduce a dual-wavelength opticalresolution photoacoustic microscopy (OR-PAM) system for functional imaging of vasculature. This system has demonstrated its application in brain glioma tumor imaging, as well as skin ischemia-reperfusion imaging.

Additional Information

© 2019 Society of Photo-optical Instrumentation Engineers (SPIE).

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Additional details

Identifiers

Eprint ID
94456
Resolver ID
CaltechAUTHORS:20190404-110210209

Dates

Created
2019-04-04
Created from EPrint's datestamp field
Updated
2021-11-16
Created from EPrint's last_modified field

Caltech Custom Metadata

Series Name
Proceedings of SPIE
Series Volume or Issue Number
10873