CaltechAUTHORS
Published June 2013 | Version public
Journal Article Metadata-only

Design and Synthesis of Oligoamide-Based Double α-Helix Mimetics

Creators

  • 1. ROR icon Yale University
  • 2. ROR icon University of Oxford
  • 3. ROR icon California Institute of Technology
  • 4. ROR icon University of Barcelona

Abstract

An extensive series of bis-oligobenzamides and bis-oligopyridylamides have been efficiently prepared and studied by X-ray analysis and computational methods. A modular synthesis led to double -helix mimics bearing between two and ten branched side-chains. The inter-helix angle and distance can be tuned by varying the length and rigidity of the spacer, thereby reproducing the recognition domains of a range of super-secondary structures.

Additional Information

© 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: March 10, 2013; published Online: May 23, 2013. The authors thank the National Science Foundation (NSF) (CHE-0750357), National Institutes of Health (NIH) (CA67771) and the University of Oxford, UK for funding.

Additional details

Identifiers

Eprint ID
39336
DOI
10.1002/ejoc.201300363
Resolver ID
CaltechAUTHORS:20130712-102051387

Funding

NSF
CHE-0750357
NIH
CA67771
University of Oxford

Dates

Created
2013-07-15
Created from EPrint's datestamp field
Updated
2021-11-09
Created from EPrint's last_modified field