CaltechAUTHORS
Published March 19, 2010 | Version Supplemental Material
Journal Article Open

Regioselective Reactions of Highly Substituted Arynes

Creators

  • 1. ROR icon California Institute of Technology

Abstract

The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functionalization of aromatic rings.

Additional Information

© 2010 American Chemical Society. Published In Issue: March 19, 2010; article ASAP: February 18, 2010; received: January 12, 2010. The authors thank The Gordon and Betty Moore Foundation, Abbott, Amgen, Boehringer- Ingelheim, Bristol-Myers Squibb, Merck, Sigma-Aldrich, Teva USA Scholars grant, The California HIV/AIDS Research Program (fellowship to P.M.T.) and Caltech for generous funding.

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Supplemental Material - ol1000796_si_001.pdf

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ol1000796_si_001.pdf

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Additional details

Identifiers

Eprint ID
17854
Resolver ID
CaltechAUTHORS:20100405-115154177

Funding

Gordon and Betty Moore Foundation
Abbot
Amgen
Boehringer-Ingelheim
Bristol-Myers Squibb
Merck
Sigma-Aldrich
Teva USA Scholars grant
California HIV/AIDS Research Program
Caltech

Dates

Created
2010-04-06
Created from EPrint's datestamp field
Updated
2021-11-08
Created from EPrint's last_modified field