The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Shen, Jia; Sheng, Xiangpeng; Chang, ZeNan; Wu, Qian; Xie, Dong; Wang, Fudi; Hu, Ronggui

doi:10.4161/23723548.2014.965642

Published 2016 | Version Published

Journal Article Open

The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into tumorigenesis associated with iron excess, but also helps guide the administration of chemotherapy based on iron deprivation in the clinic.

Additional Information

© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC© Jia Shen, Xiangpeng Sheng, ZeNan Chang, Qian Wu, Dong Xie, Fudi Wang, and Ronggui Hu. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. Submitted: 08/11/2014; Revised: 08/13/2014; Accepted: 08/13/2014. The authors truly appreciate the support from all collaborators and funding from the Ministry of Science and Technology of China (2010CB912101, 2012CB910800, 2013CB910900, 2011CB915501), the National Natural Science Foundation of China (31270828, 31070678), Chinese Academy of Sciences (Instrument Developing Project YZ201339), Cancer Center of SIBS-Xuhui Central Hospital (CCR2012003), and Shanghai Institute of Neurosciences (SKLN-201206). No potential conflicts of interest were disclosed.

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