Published July 1996
| Version public
Journal Article
Sequence-specific recognition of DNA by a major and minor groove binding ligand
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1.
California Institute of Technology
Abstract
A combination of the binding models for the simultaneous recognition of both grooves of DNA led to the design of a polyamide–oligonucleotide ligand that binds to a specific DNA sequence with an association constant of K_a > 2 × 10^(10) M^(−1). The oligonucleotide portion forms a triple helix in the major groove of DNA, and the polyamide unit forms a hairpin in the minor groove (see ribbon model below).
Additional Information
© 1996 VCH Verlagsgesellschuft mbH. Received: March 3. 1996. We are grateful to the National Institutes of Health for support (GM-27681) and to the Howard Hughes Medical Institute for a Predoctoral Fellowship to E. E. B.Additional details
Identifiers
- Eprint ID
- 66885
- Resolver ID
- CaltechAUTHORS:20160510-102930862
Funding
- NIH
- GM-27681
- Howard Hughes Medical Institute (HHMI)
Dates
- Created
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2016-05-18Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field