CaltechAUTHORS
Published April 2016 | Version public
Book Section - Chapter Metadata-only

MEMS oxygen transport device for islet transplantation in the subcutaneous site

Creators

  • 1. ROR icon California Institute of Technology

Abstract

This paper presents a new MEMS approach of maintaining islet oxygenation for subcutaneous islet transplantation therapy of type 1 diabetes by engineering a MEMS oxygen transport device. A device is designed and fabricated. Bench-top testing and computational modeling of the device have demonstrated that it would provide sufficient oxygen to prevent hypoxia-induced islet death and maintain the functional metabolic activity of glucose-simulated insulin secretion for islets transplanted subcutaneously.

Additional Information

© 2016 IEEE. This work is financially supported by City of Hope. The authors gratefully acknowledge the help of all the members from the Caltech Micromachining Lab and City of Hope's Diabetes and Metabolic Researches Department.

Additional details

Identifiers

Eprint ID
72688
Resolver ID
CaltechAUTHORS:20161209-093102216

Related works

Describes
10.1049/mnl.2016.0303 (DOI)

Funding

City of Hope

Dates

Created
2016-12-09
Created from EPrint's datestamp field
Updated
2021-11-11
Created from EPrint's last_modified field