CaltechAUTHORS
Published February 6, 2009 | Version Published
Journal Article Open

Response to comment on "Human-specific gain of function in a developmental enhancer"

Creators

  • 1. ROR icon Lawrence Berkeley National Laboratory
  • 2. ROR icon Western General Hospital
  • 3. ROR icon Joint Genome Institute

Abstract

Duret and Galtier argue that human-specific sequence divergence and gain of function in the HACNS1 enhancer result from deleterious biased gene conversion (BGC) with no contribution from positive selection. We reinforce our previous conclusion by analyzing hypothesized BGC events genomewide and assessing the effect of recombination rates on human-accelerated conserved noncoding sequence ascertainment. We also provide evidence that AT → GC substitution bias can coexist with positive selection.

Additional Information

Copyright 2009 by the American Association for the Advancement of Science. 28 October 2008; accepted 12 January 2009.

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Published - PRAsci09.pdf

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Identifiers

Eprint ID
13778
Resolver ID
CaltechAUTHORS:PRAsci09

Dates

Created
2009-03-23
Created from EPrint's datestamp field
Updated
2021-11-08
Created from EPrint's last_modified field