Published July 18, 2011
| Version Supplemental Material + Accepted Version
Journal Article
Open
The Catalytic Enantioselective Total Synthesis of (+)-Liphagal
Abstract
Ring a ding: The meroterpenoid natural product (+)-liphagal has been synthesized enantioselectively in 19 steps from commercially available materials. The trans-homodecalin system was achieved by ring expansion followed by stereoselective hydrogenation.
Additional Information
© 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: March 15, 2011; Article first published online: 10 June 2011. This publication is based on work supported by Award No. KUS-11-006-02, made by the King Abdullah University of Science and Technology (KAUST). We wish to thank the NIH-NIGMS (R01M080269-01), the Gordon and Betty Moore Foundation, Abbott, Amgen, Boehringer Ingelheim, and Caltech for generous funding. R.M.M. thanks Eli Lilly for a graduate fellowship. H.K. acknowledges the travelling scholarship of the Danish Technical University, the Jorcks foundation, and the Otto Mønsteds foundation for financial support. J.L.A. gratefully acknowledges the Amgen Foundation for funding through the Amgen Scholars program. We thank Prof. E. N. Jacobsen and Dr. S. J. Zuend for a kind donation of both (R)-t-leucine and their optimal Strecker catalyst.Attached Files
Accepted Version - nihms377541.pdf
Supplemental Material - anie_201101842_sm_miscellaneous_information.pdf
Files
anie_201101842_sm_miscellaneous_information.pdf
Additional details
Identifiers
- PMCID
- PMC3361906
- Eprint ID
- 24168
- Resolver ID
- CaltechAUTHORS:20110622-115436125
Funding
- King Abdullah University of Science and Technology (KAUST)
- KUS-11- 006-02
- NIH
- R01M080269-01
- Gordon and Betty Moore Foundation
- Abbott
- Amgen
- Boehringer Ingelheim
- Caltech
- Eli Lilly
- Danish Technical University
- Jorcks foundation
- Otto Mønsteds Foundation
- AmGen Scholars Program
Dates
- Created
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2011-07-19Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field