DNA interference and beyond: structure and functions of prokaryotic Argonaute proteins
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1.
Institute of Molecular Genetics
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2.
California Institute of Technology
Abstract
Recognition and repression of RNA targets by Argonaute proteins guided by small RNAs is the essence of RNA interference in eukaryotes. Argonaute proteins with diverse structures are also found in many bacterial and archaeal genomes. Recent studies revealed that, similarly to their eukaryotic counterparts, prokaryotic Argonautes (pAgos) may function in cell defense against foreign genetic elements but, in contrast, preferably act on DNA targets. Many crucial details of the pAgo action, and the roles of a plethora of pAgos with non-conventional architecture remain unknown. Here, we review available structural and biochemical data on pAgos and discuss their possible functions in host defense and other genetic processes in prokaryotic cells.
Additional Information
© 2018 the Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received: 2 February 2018 Accepted: 26 October 2018. Published: 04 December 2018. We apologize to many colleagues whose work is not cited due to space limitations. This work was supported by the Grant of the Ministry of Education and Science of Russian Federation 14.W03.31.0007. Author Contributions: L.L., A.A.A. and A.K. analyzed the data. L.L. and A.K. prepared the figures. A.A.A. and A.K. wrote the manuscript. Data availability: No datasets were generated or analysed during the current study. The authors declare no competing interests.
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Supplemental Material - 41467_2018_7449_MOESM1_ESM.pdf
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41467_2018_7449_MOESM1_ESM.pdf
Additional details
Identifiers
- PMCID
- PMC6279821
- Eprint ID
- 91436
- Resolver ID
- CaltechAUTHORS:20181204-130810931
Funding
- Ministry of Education and Science of the Russian Federation
- 14.W03.31.0007
Dates
- Created
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2018-12-05Created from EPrint's datestamp field
- Updated
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2022-03-02Created from EPrint's last_modified field