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Published August 1978 | Version Published
Journal Article Open

A Drosophila Mutant with a Temperature-Sensitive Block in Nerve Conduction

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Abstract

A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired. Larvae and adults are rapidly paralyzed at restrictive temperatures; they recover rapidly when the temperature is decreased. The mutant gene is recessive and is located on the second chromosome at map position 56.

Additional Information

© 1978 National Academy of Sciences. Contributed by Seymour Benzer, May 26, 1978. We thank our colleagues for constant comment, particularly Lawrence Kauvar and Duncan Byers. This work was supported by National Science Foundation Grant PCM73-01972. C-F.W., B.G., Y-N.J., and L.Y.J. held fellowships from, respectively, the Spencer, Jane Coffin Childs, and Muscular Dystrophy Foundations and the National Institutes of Health.

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Published - WUCpnas78.pdf

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Additional details

Identifiers

PMCID
PMC392928
Eprint ID
4747
Resolver ID
CaltechAUTHORS:WUCpnas78

Related works

Describes
http://www.pnas.org/cgi/content/abstract/75/8/4047 (URL)

Funding

NSF
PCM73-01972
Spencer Foundation
Jane Coffin Childs Foundation
Muscular Dystrophy Foundation
NIH

Dates

Created
2006-09-05
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Updated
2019-10-02
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