CaltechAUTHORS
Published September 1, 2000 | Version public
Journal Article Metadata-only

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

Creators

  • 1. ROR icon Buck Institute for Research on Aging
  • 2. ROR icon University of Manchester
  • 3. ROR icon Emory University

Abstract

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

Additional Information

© 2000 American Association for the Advancement of Science. 27 March 2000; accepted 11 July 2000. We thank the Lithgow lab and A. Seyed Jazayeri-Dezfuly for critical and helpful discussions. M.S.G. is a Medical Research Council (MRC)-supported Training Fellow. D.W.W. is also supported by the MRC, and S. Malik was supported by Research into Aging. D.C.W. and S. Melov were supported in part by NIH grants AG-13154 and NS21328, awarded to D.C.W. All strains were obtained from the Caenorhabditis Genetics Center.

Additional details

Identifiers

Eprint ID
51713
Resolver ID
CaltechAUTHORS:20141113-130428662

Funding

Medical Research Council (MRC)
Research into Aging
NIH
AG-13154
NIH
NS21328

Dates

Created
2014-11-14
Created from EPrint's datestamp field
Updated
2021-11-10
Created from EPrint's last_modified field