Published February 9, 2009
| Version Accepted Version + Supplemental Material
Journal Article
Open
Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides
Creators
-
1.
University of Chicago
Abstract
Small with control: For miniaturization of protein aggregation experiments the interfacial chemistry must be controlled to avoid protein aggregation caused by interfacial adsorption. Plug-based microfluidics with defined surface chemistry (see schematic picture) can then be used to perform hundreds of aggregation experiments with volume-limited samples, such as cerebrospinal fluid from mice.
Additional Information
Copyright © 2009 WILEY-VCH. Issue published online: 30 JAN 2009. Article first published online: 16 JAN 2009. Manuscript Received: 25 OCT 2008. This research was supported by the National Institutes of Health NIBIB EB000557 and the NIH Director's Pioneer Award DP1 OD003584 to R.F.I. and by Cure Alzheimer's Fund and NIH AG027854 to S.S.S. R.F.I. is a Camille Dreyfus Teacher-Scholar. M.M. was supported by the Alexander von Humboldt Society and J.K.-D. by the NIH Roadmap training program T90 DK070076. We thank Dr. A. M. Seddon and Dr. E. Chan for preliminary experiments and E. W. Haney for editing this manuscript.Attached Files
Accepted Version - nihms101444.pdf
Supplemental Material - Ismagilov_Angew_Chem_2009_aggregation_48_1487_1489_MM_JKD_supp_info.pdf
Files
Ismagilov_Angew_Chem_2009_aggregation_48_1487_1489_MM_JKD_supp_info.pdf
Additional details
Identifiers
- PMCID
- PMC2675571
- Eprint ID
- 40836
- DOI
- 10.1002/anie.200805225
- Resolver ID
- CaltechAUTHORS:20130821-160725760
Funding
- NIH
- EB000557
- NIH
- 1DP1 OD003584
- Cure Alzheimer's Fund
- NIH
- AG027854
- Camille and Henry Dreyfus Foundation
- Alexander von Humboldt Foundation
- NIH Predoctoral Fellowship
- T90 DK070076
Dates
- Created
-
2013-08-26Created from EPrint's datestamp field
- Updated
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2023-06-02Created from EPrint's last_modified field