CaltechAUTHORS
Published December 24, 1982 | Version public
Journal Article Metadata-only

Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas

Creators

  • 1. ROR icon California Institute of Technology
  • 2. ROR icon University of California, Los Angeles

Abstract

Hybridization studies with viral oncogene probes indicate that c-myc, the cellular gene homologous to the transforming gene of avian myelocytomatosis virus, resides on mouse chromosome 15 and in many plasmacytomas is translocated to the antibody heavy chain gene locus on chromosome 12. The transcriptional orientation of the translocated c-myc sequence is opposite the orientation of the adjacent C alpha gene that codes for the heavy chain of immunoglobulin A. The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay.

Additional Information

© 1982 American Association for the Advancement of Science. Submitted 21 October 1982. Published 24 December 1982. We thank M. Lane and G. Cooper for providing the S107/NIH-3T3 transformed cell lines and S. Aaronson, J.M. Bishop, M. Cline, and D. Slamon for providing cloned oncogenes. Supported by NIH grants (L.H. and K.C.) and by postdoctoral fellowship from the Anna Fuller Fund (R.B.).

Additional details

Identifiers

Eprint ID
54230
DOI
10.1126/science.7146913
Resolver ID
CaltechAUTHORS:20150129-123414091

Related works

Describes
10.1126/science.7146913 (DOI)
http://www.jstor.org/stable/1690204 (URL)

Funding

National Institutes of Health (NIH)
Anna Fuller Fund

Dates

Created
2015-01-30
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Updated
2021-11-10
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