CaltechAUTHORS
Published September 1992 | Version public
Journal Article Metadata-only

The echinoid immune system and the phylogenetic occurrence of immune mechanisms in deuterostomes

Creators

  • 1. ROR icon California Institute of Technology

Abstract

In this article, Courtney Smith and Eric Davidson reinterpret the published data on immune function in lower deuterostomes and primitive chordates. It leads them to a new model of immune system phylogeny in which MHC-directed T-cell responses are the last to evolve and are not derived from subchordate self-nonself recognition systems.

Additional Information

© 1992 Elsevier Science Publishers Ltd, UK. We wish to thank Ellen Rothenberg of Caltech for insightful discussions of the ideas in this manuscript. We are grateful to Gary Littman of All Childrens Hospital, University of S. Florida and Charles Janeway of Yale University for their valuable comments. This work was supported by a Developmental Biology Grant from the Lucille P. Markey Charitable Trust.

Additional details

Identifiers

Eprint ID
63160
Resolver ID
CaltechAUTHORS:20151222-160437263

Funding

Lucille P. Markey Charitable Trust

Dates

Created
2015-12-23
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Updated
2021-11-10
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