CaltechAUTHORS
Published February 1957 | Version public
Journal Article Metadata-only

The Biosynthesis of the Triterpene, Eburicoic Acid: The Utilization of Methyl-labeled Acetate

Creators

Abstract

The C_(31)-triterpene, eburicoic acid, has been biosynthesized by allowing P. sulfureus to grow on a medium containing methyl-labeled acetate. By degradation of the acid, it has been shown that the carboxyl carbon, C_(21), and the two methyl groups, C_(30) and C_(31), of the gem-dimethyl group of ring A are derived from the methyl of acetate. Such a distribution is predicted on the basis of the squalene hypothesis of a "universal" biosynthetic mechanism leading to both the triterpenes and the sterols. It also was found that the extra carbon atom, C_(28), found on C_(24) of the side-chain is not derived from acetate.

Additional Information

© 1957 American Chemical Society. Received July 16, 1956. This work was supported, in part, by grant No. AT(11-1)-34, Project No. 16, U.S. Atomic Energy Commission. [JRH] National Science Foundation Predoctoral Fellow, 1954-1955.

Additional details

Identifiers

Eprint ID
57050
DOI
10.1021/ja01561a052
Resolver ID
CaltechAUTHORS:20150428-125502290

Related works

Describes
10.1021/ja01561a052 (DOI)

Funding

Atomic Energy Commission
AT(11-1)-34
NSF Predoctoral Fellowship

Dates

Created
2015-04-28
Created from EPrint's datestamp field
Updated
2021-11-10
Created from EPrint's last_modified field