Published November 2012
| Version Supplemental Material + Published
Journal Article
Open
A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines
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1.
California Institute of Technology
Abstract
An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient temperatures and with equimolar quantities of the coupling partners.
Additional Information
© 2012 The Royal Society of Chemistry. Received 9th July 2012, Accepted 9th August 2012. First published on the web 17 Aug 2012. We thank Prof. Brian Stoltz, Dr. Scott Virgil, and the Caltech Center for Catalysis and Chemical Synthesis for access to analytical equipment. We also thank Sigma-Aldrich for a kind donation of chemicals. Fellowship support was provided by the National Science Foundation (Graduate Research Fellowship, M.E.K, Grant no. DGE-1144469). Financial support from the California Institute of Technology and the NIH (NIGMS RGM097582A) is gratefully acknowledged.Attached Files
Published - c2sc20914d.pdf
Supplemental Material - c2sc20914d_supp.pdf
Files
c2sc20914d.pdf
Additional details
Identifiers
- PMCID
- PMC3480223
- Eprint ID
- 35975
- Resolver ID
- CaltechAUTHORS:20121213-102648677
Funding
- NSF Graduate Research Fellowship
- DGE-1144469
- Caltech
- NIH
- RGM097582A
Dates
- Created
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2012-12-17Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field