CaltechAUTHORS
Published January 1948 | Version public
Journal Article Metadata-only

Studies on the Denaturation of Antibody. III. Kinetic Aspects of the Inactivation of Diphtheria Antitoxin by Urea

Creators

Abstract

In the present investigation we have studied the effects of pH, urea concentration, and temperature on the inactivation reaction, in order to explore the influence of these factors on its abnormalities. The experimental results are shown to be compatible with a simple kinetic mechanism.

Additional Information

© 1948 American Chemical Society. Received July 2, 1947. This investigation was carried out with the aid of a grant from The Rockefeller Foundation. The authors are indebted to Professor Linus Pauling for suggestions and discussion, to J. Y. Chien for carrying out preliminary experiments on the effect of temperature, and to Sharp and Dohme, Glenolden, Pennsylvania, for supplying the antitoxin and toxin

Additional details

Identifiers

Eprint ID
88185
DOI
10.1021/ja01181a111
Resolver ID
CaltechAUTHORS:20180724-121639493

Related works

Describes
10.1021/ja01181a111 (DOI)

Funding

Rockefeller Foundation

Dates

Created
2018-07-24
Created from EPrint's datestamp field
Updated
2021-11-16
Created from EPrint's last_modified field

Caltech Custom Metadata

Other Numbering System Name
Gates and Crellin Laboratories of Chemistry
Other Numbering System Identifier
1072