CaltechAUTHORS
Published July 22, 2022 | Version Submitted + Supplemental Material
Discussion Paper Open

Symbiosis-driven development in an early branching metazoan

Creators

  • 1. ROR icon Pennsylvania State University
  • 2. ROR icon National Museum of Natural History
  • 3. ROR icon Florida International University
  • 4. ROR icon University of Colorado Boulder
  • 5. ROR icon University of Florida
  • 6. ROR icon New College of Florida
  • 7. ROR icon California Institute of Technology
  • 8. ROR icon Berry College
  • 9. ROR icon Joint Genome Institute
  • 10. ROR icon University of California, Berkeley
  • 11. ROR icon Swarthmore College
  • 12. ROR icon University of Hong Kong
  • 13. ROR icon University of Georgia

Abstract

Microbes can initiate developmental gene regulatory cascades in animals. The molecular mechanisms underlying microbe-induced animal development and the evolutionary steps to integrate microbial signals into regulatory programs remain poorly understood. In the upside-down jellyfish Cassiopea xamachana, a dinoflagellate endosymbiont initiates the life stage transition from the sessile polyp to the sexual medusa. We found that metabolic products derived from symbiont carotenoids may be important to initiate C. xamachana development, in addition to expression of conserved genes involved in medusa development of non-symbiotic jellyfish. We also revealed the transcription factor COUP is expressed during metamorphosis, potentially as a co-regulator of nuclear receptor RXR. These data suggest relatively few steps may be necessary to integrate symbiont signals into gene regulatory networks and cements the role of the symbiont as a key trigger for life history transition in C. xamachana.

Additional Information

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. The work conducted by the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The authors have declared no competing interest.

Attached Files

Submitted - 2022.07.21.500558v1.full.pdf

Supplemental Material - media-1.pdf

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2022.07.21.500558v1.full.pdf

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Additional details

Identifiers

Eprint ID
115809
Resolver ID
CaltechAUTHORS:20220725-414384000

Funding

Department of Energy (DOE)
DE-AC02-05CH11231

Dates

Created
2022-07-27
Created from EPrint's datestamp field
Updated
2022-07-27
Created from EPrint's last_modified field

Caltech Custom Metadata

Caltech groups
Division of Biology and Biological Engineering (BBE)