Published February 1, 2016
| Version Supplemental Material + Published
Journal Article
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Palladium-catalyzed C(sp^3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids
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1.
Zhejiang University
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2.
California Institute of Technology
Abstract
A Pd-catalyzed arylation of lactic acid employing 8-aminoquinoline as the directing group has been reported. The protocol is found to be compatible with a broad range of synthetically useful functional groups, thus providing a practical route to chiral β-aryl-α-hydroxy acids. Further, the new reaction has also been applied to the synthesis of pharmaceutically important α-hydroxy acids, such as LY519818 and tesaglitazar.
Additional Information
© Royal Society of Chemistry 2016. Received 17 Oct 2015; accepted 03 Dec 2015; first published online 07 Dec 2015. This article is part of themed collection: 2015 Emerging Investigators by OCF. Financial support from the National Basic Research Program of China (2015CB856600) and the NSFC (21572201, 21422206, 21272206) is gratefully acknowledged.Attached Files
Published - c5qo00319a.pdf
Supplemental Material - c5qo00319a1.pdf
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c5qo00319a.pdf
Additional details
Additional titles
- Alternative title
- Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids
Identifiers
- Eprint ID
- 64791
- Resolver ID
- CaltechAUTHORS:20160226-083615257
Funding
- National Basic Research Program of China
- 2015CB856600
- Natural Science Foundation of China
- 21572201
- Natural Science Foundation of China
- 21422206
- Natural Science Foundation of China
- 21272206
Dates
- Created
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2016-02-29Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field