CaltechAUTHORS
Published November 18, 2014 | Version Published
Journal Article Open

A cytotoxic and cytostatic gold(III) corrole

Creators

  • 1. ROR icon California Institute of Technology
  • 2. ROR icon Technion – Israel Institute of Technology

Abstract

We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.

Additional Information

© 2014 The Royal Society of Chemistry. Received 21st August 2014, Accepted 4th September 2014, First published online 05 Sep 2014. We thank Roger E. Moore of the Mass Spectrometry and Proteomics Core (City of Hope) for technical assistance. Our work is supported by the Caltech-City of Hope Biomedical Research Initiative (H.B.G., J.T., Z.G.) and the Caltech Summer Undergraduate Research Fellowship program (D.R.T.).

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Additional details

Identifiers

Eprint ID
50070
Resolver ID
CaltechAUTHORS:20140926-131926805

Funding

Caltech-City of Hope Biomedical Research Initiative
Caltech Summer Undergraduate Research Fellowship (SURF)

Dates

Created
2014-10-09
Created from EPrint's datestamp field
Updated
2021-11-10
Created from EPrint's last_modified field