CaltechAUTHORS
Published November 27, 2006 | Version Accepted Version
Journal Article Open

The synthesis of C-3β functionalized indoles via a hydroboration/Suzuki–Miyaura coupling sequence

Creators

  • 1. ROR icon California Institute of Technology

Abstract

A method for the functionalization of C-3β of vinyl indoles is described. The procedure involves a hydroboration, followed by a Suzuki–Miyaura cross-coupling with the intermediate alkyl borane. Triflates, bromides, and iodides are suitable coupling partners, allowing access to a variety of elaborated indole compounds.

Additional Information

© 2006 Elsevier Ltd. Received 1 September 2006, Accepted 21 September 2006, Available online 13 October 2006. The authors wish to thank the NIH-NIGMS (R01 GM65961-01), Bristol-Myers Squibb Company (graduate fellowship to E.M.F.), the NSF (graduate fellowship to E.M.F.), the Dreyfus Foundation, Merck Research Laboratories, Research Corporation, Abbott Laboratories, Pfizer, Amgen, GlaxoSmithKline, Lilly, and Johnson and Johnson for their generous financial support.

Attached Files

Accepted Version - nihms-13692.pdf

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Additional details

Identifiers

PMCID
PMC1832155
Eprint ID
72291
DOI
10.1016/j.tetlet.2006.09.112
Resolver ID
CaltechAUTHORS:20161128-080903512

Related works

Describes
10.1016/j.tetlet.2006.09.112 (DOI)

Funding

NIH
R01GM65961-01
Bristol-Myers Squibb Company
NSF
Camille and Henry Dreyfus Foundation
Merck Research Laboratories
Research Corporation
Abbott Laboratories
Pfizer
Amgen
GlaxoSmithKline
Lilly
Johnson and Johnson

Dates

Created
2016-11-28
Created from EPrint's datestamp field
Updated
2021-11-11
Created from EPrint's last_modified field