CaltechAUTHORS
Published September 10, 1987 | Version public
Journal Article Metadata-only

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

Creators

  • 1. ROR icon Massachusetts Institute of Technology

Abstract

The RAD6 gene of the yeast Saccharomyces cerevisiae is required for a variety of cellular functions including DNA repair. The discovery that the RAD6 gene product can catalyse the covalent attachment of ubiquitin to other proteins suggests that the multiple functions of the RAD6 protein are mediated by its ubiquitin-conjugating activity.

Additional Information

© 1987 Nature Publishing Group. Received 25 June; accepted 17 July 1987. We thank Daniel Finley for helpful discussions and advice; Paul Matsudaira for communicating his protein transfer/sequencing procedure before publication; William Lane for protein sequencing; Andreas Bachmair, Bonnie Bartel, Daniel Finley and Mark Hochstrasser for comments on the manuscript; and Barbara Doran for secretarial assistance. This work was supported by a grant to A.V. from the National Institute of General Medical Sciences. S.J. was supported by a fellowship from the Deutsche Forschungsgemeinschaft.

Additional details

Identifiers

Eprint ID
107682
DOI
10.1038/329131a0
Resolver ID
CaltechAUTHORS:20210122-162657916

Related works

Describes
10.1038/329131a0 (DOI)

Funding

NIH
National Institute of General Medical Sciences
Deutsche Forschungsgemeinschaft (DFG)

Dates

Created
2021-01-25
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Updated
2021-11-16
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