CaltechAUTHORS
Published September 14, 2011 | Version Accepted Version + Supplemental Material
Journal Article Open

De Novo Design of Bioactive Protein-Resembling Nanospheres via Dendrimer-Templated Peptide Amphiphile Assembly

Creators

  • 1. ROR icon University of California, Santa Barbara
  • 2. ROR icon University of California, Berkeley
  • 3. ROR icon Columbia University

Abstract

Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.

Additional Information

© 2011 American Chemical Society. Received: June 30, 2011. Revised: July 27, 2011. Published: August 01, 2011. This work was supported by the MRSEC Program of the NSF under Award No. DMR05-20415, the National Institutes of Health as a Program of Excellence in Nanotechnology under Award Nos. NIH1U01 HL080718, HHSN268201000046C, the CCNE Program of the National Institutes of Health under Award No. NIH1U54 CA119335, and the UC Berkeley College of Engineering. M.J.R thanks the DOE Office of Science for a Graduate Fellowship. The authors thank P. Allen for the artistic renderings, the R. Segalman lab for use of their DLS, and the T. Xu lab for use of their AFM. The authors declare no competing financial interests.

Attached Files

Accepted Version - nihms-315671.pdf

Supplemental Material - nl202220q_si_001.pdf

Files

nihms-315671.pdf

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Additional details

Identifiers

PMCID
PMC3223106
Eprint ID
86840
DOI
10.1021/nl202220q
Resolver ID
CaltechAUTHORS:20180606-111128037

Related works

Describes
10.1021/nl202220q (DOI)

Funding

NSF
DMR05-20415
NIH
1U01 HL080718
NIH
HHSN268201000046C
NIH
1U54 CA119335
UC Berkeley College of Engineering
Department of Energy (DOE)

Dates

Created
2018-06-06
Created from EPrint's datestamp field
Updated
2021-11-15
Created from EPrint's last_modified field