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Published January 8, 2020 | Version Published
Journal Article Open

Alliance of Genome Resources Portal: unified model organism research platform

Creators

Abstract

The Alliance of Genome Resources (Alliance) is a consortium of the major model organism databases and the Gene Ontology that is guided by the vision of facilitating exploration of related genes in human and well-studied model organisms by providing a highly integrated and comprehensive platform that enables researchers to leverage the extensive body of genetic and genomic studies in these organisms. Initiated in 2016, the Alliance is building a central portal (www.alliancegenome.org) for access to data for the primary model organisms along with gene ontology data and human data. All data types represented in the Alliance portal (e.g. genomic data and phenotype descriptions) have common data models and workflows for curation. All data are open and freely available via a variety of mechanisms. Long-term plans for the Alliance project include a focus on coverage of additional model organisms including those without dedicated curation communities, and the inclusion of new data types with a particular focus on providing data and tools for the non-model-organism researcher that support enhanced discovery about human health and disease. Here we review current progress and present immediate plans for this new bioinformatics resource.

Additional Information

© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Received: 31 July 2019; Revision received: 03 September 2019; Accepted: 19 September 2019; Published: 25 September 2019. The Alliance platform is designed and implemented by a core group of developers and curators at SGD, WormBase, ZFIN, RGD, MGD, FlyBase and the GOC. We would particularly like to acknowledge other staff at those projects who continue to provide gold-standard curation of model organism data without which the work described here would not be possible. Funding: National Institutes of Health/National Human Genome Research Institute grant [U24HG002223-19S1]; National Institutes of Health/National Human Genome Research Institute grants [P41HG002659 (ZFIN), U24HG002223 (WormBase), U41HG000739 (FlyBase), U41HG001315 (SGD), HG000330 (MGD), U41HG002273] (GOC, which also provides funding to W.B., M.G.D., S.G.D.); National Institutes of Health/National Heart, Lung and Blood Institute [HL64541 to R.G.D.]; Medical Research Council-UK [MR/L001020/1 (WormBase)]. Funding for open access charge: National Institutes of Health/National Human Genome Research Institute grant [1U24HG010859-01]. Conflict of interest statement. None declared.

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Additional details

Identifiers

PMCID
PMC6943066
Eprint ID
102491
Resolver ID
CaltechAUTHORS:20200413-081503928

Funding

NIH
U24HG002223-19S1
NIH
P41HG002659
NIH
U24HG002223
NIH
U41HG000739
NIH
U41HG001315
NIH
HG000330
NIH
U41HG002273
NIH
HL64541
Medical Research Council (UK)
MR/L001020/1
NIH
1U24HG010859-01

Dates

Created
2020-04-13
Created from EPrint's datestamp field
Updated
2021-11-16
Created from EPrint's last_modified field

Caltech Custom Metadata

Caltech groups
Division of Biology and Biological Engineering (BBE)