Published July 26, 2017
| Version Published
Journal Article
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Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S_N1 and S_N2 Processes
Abstract
Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (S_N1 and S_N2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transition-metal complexes provide an attractive approach to addressing these limitations
Additional Information
© 2017 American Chemical Society. ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Received 18 May 2017. Published online 12 June 2017. Support has been provided by the National Institutes of Health (National Institute of General Medical Sciences: R01-GM062871 and R01-GM109194). All group members past and present, as well as Prof. Jonas C. Peters and his group, are gratefully acknowledged for their contributions to this research program. The author declares no competing financial interest.Attached Files
Published - acscentsci.7b00212.pdf
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acscentsci.7b00212.pdf
Additional details
Identifiers
- PMCID
- PMC5532721
- Eprint ID
- 78161
- DOI
- 10.1021/acscentsci.7b00212
- Resolver ID
- CaltechAUTHORS:20170613-111718684
Funding
- NIH
- R01-GM062871
- NIH
- R01-GM109194
Dates
- Created
-
2017-06-13Created from EPrint's datestamp field
- Updated
-
2022-03-25Created from EPrint's last_modified field