Cp_2TiCH_2 complexes in synthetic applications
Abstract
The reactive 16e- species Cp_2Ti=CH_2 can be generated in situ from either its aluminum alkyl adducts or olefin adducts (metallacyclobutanes). This complex reacts with a wide variety of unsaturated functionalities including c=O, c=C,-c≡c- and –C≡N. In most instances the c:O groups are methylenated. Key to the utility of these complexes is their lack of basic properties in contrast with phosphorous ylides; all of the normal "Wittig" side reactions are eliminated using these reagents. Acid chlorides and anhydrides are converted into enolate complexes, which can be used in aldol type chemistry. The combination of the reactivity toward C=O and C=C results in an efficient method for the conversion of unhindered carbonyl centers into quarternary carbon centers.
Additional Information
© 1983 IUPAC. The authors gratefully acknowledge the financial support of the National Science Foundation and the National Institutes of Health.Attached Files
Published - _Pure_and_Applied_Chemistry__Cp2TiCH2_complexes_in_synthetic_applications.pdf
Files
_Pure_and_Applied_Chemistry__Cp2TiCH2_complexes_in_synthetic_applications.pdf
Additional details
Additional titles
- Alternative title
- Cp2TiCH2 complexes in synthetic applications
Identifiers
- Eprint ID
- 88652
- Resolver ID
- CaltechAUTHORS:20180808-095501993
Funding
- NSF
- NIH
Dates
- Created
-
2018-08-08Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
Caltech Custom Metadata
- Other Numbering System Name
- Caltech Laboratories of Chemistry
- Other Numbering System Identifier
- 6891