CaltechAUTHORS
Published May 2016 | Version Published
Journal Article Open

Phase-field model for collective cell migration

Creators

  • 1. ROR icon California Institute of Technology
  • 2. ROR icon McGill University

Abstract

We construct a phase-field model for collective cell migration based on a Ginzburg-Landau free-energy formulation. We model adhesion, surface tension, repulsion, coattraction, and polarization, enabling us to follow the cells' morphologies and the effect of their membranes fluctuations on collective motion. We were able to measure the tissue surface tension as a function of the individual cell cortical tension and adhesion and identify a density threshold for cell-sheet formation.

Additional Information

© 2016 American Physical Society. Received 10 November 2015; published 9 May 2016. We acknowledge support from the Natural Sciences and Engineering Research Council of Canada, le Fonds de recherche du Québec—Nature et technologies, and discussions with Iain Couzin and members of the Couzin Lab at Princeton University.

Attached Files

Published - PhysRevE.93.052405.pdf

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PhysRevE.93.052405.pdf

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Additional details

Identifiers

Eprint ID
67347
Resolver ID
CaltechAUTHORS:20160525-105207767

Funding

Natural Sciences and Engineering Research Council of Canada (NSERC)
Fonds de recherche du Québec-Nature et Technologies (FRQ-NT)

Dates

Created
2016-05-26
Created from EPrint's datestamp field
Updated
2021-11-11
Created from EPrint's last_modified field