Published December 1988
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Journal Article
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Free boundary problems in controlled release pharmaceuticals: II. swelling-controlled release
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Abstract
A problem in controlled release pharmaceutical systems is formulated and studied. The device modeled is a polymer matrix containing an initially immobilized drug. The release of the drug is achieved by countercurrent diffusion through a penetrant solvent with the release rate being determined by the rate of diffusion of the solvent in the polymer. The mathematical theory yields a free boundary problem which is studied in various asymptotic regimes.
Additional Information
©1988 Society for Industrial and Applied Mathematics. Received by the editors September 10, 1986; accepted for publication (in revised form) September 16, 1987. [D.S.C] was supported in part by U.S. Army Research Office (Durham) under contract DAAG29-85-K-0092, by the National Science Foundation under grant DMS-8706642, and by the Department of Energy under grant 7405/ENG-36 at the Center for Nonlinear Studies at Los Alamos. [T.E] was supported in part by the Air Force Office of Scientific Research under grant AFOSR85-0150 and the National Science Foundation under grant DMS-8701302.Attached Files
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Identifiers
- Eprint ID
- 12669
- Resolver ID
- CaltechAUTHORS:COHsiamjam88b
Funding
- Army Research Office
- DAAG29-85-K-0092
- National Science Foundation
- DMS-8706642
- Department of Energy
- 7405/ENG-36
- Air Force Office of Scientific Research
- AFOSR85-0150
- National Science Foundation
- DMS-8701302
Dates
- Created
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2008-12-24Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field
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