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Published September 1, 2004 | Version Published
Journal Article Open

Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent

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Abstract

We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.

Additional Information

© 2004 Optical Society of America. Received April 2, 2004. We thank several colleagues for suggesting the use of ICG as a MCOCT contrast agent, most notably Hubert van den Bergh. This research was supported by National Institutes of Health grant EB000243.

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Identifiers

PMCID
PMC1283115
Eprint ID
2806
Resolver ID
CaltechAUTHORS:YANol04

Related works

Describes
http://www.opticsinfobase.org/abstract.cfm?URI=ol-29-17-2016 (URL)

Funding

NIH
EB000243

Dates

Created
2006-04-28
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Updated
2020-03-09
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