CaltechAUTHORS
Published February 2010 | Version Published
Journal Article Open

Photoacoustic microscopy with 2-μm transverse resolution

Creators

  • 1. ROR icon Washington University in St. Louis

Abstract

We present a new-generation optical-resolution confocal photoacoustic microscope, consisting of a 0.25–numerical aperture optical microscope objective and a 75-MHz center-frequency spherically focused ultrasonic transducer. Experiments verified that this microscope has a transverse resolution of 2μm, which is the highest to our knowledge among all photoacoustic imaging systems. In situ imaging of mouse ears shows the feasibility of resolving individual red blood cells in microvessels using the current system.

Additional Information

© 2010 SPIE. Paper 09322SSR received Jul. 31, 2009; revised manuscript received Dec. 16, 2009; accepted for publication Dec. 17, 2009; published online Mar. 25, 2010. We thank Younan Xia's group for providing gold nanocages. This work was supported in part by National Institutes of Health Grants No. R01 NS46214 (BRP), No. R01 EB000712, No. R01 EB008085, and No. U54 CA136398 (NTR). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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Additional details

Identifiers

PMCID
PMC2857454
Eprint ID
70207
Resolver ID
CaltechAUTHORS:20160908-103450834

Funding

NIH
R01 NS46214
NIH
R01 EB000712
NIH
R01 EB008085
NIH
U54 CA136398

Dates

Created
2016-09-08
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Updated
2021-11-11
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