CaltechAUTHORS
Published April 2022 | Version Published
Journal Article Open

WormBase in 2022—data, processes, and tools for analyzing Caenorhabditis elegans

Creators

  • 1. ROR icon European Bioinformatics Institute
  • 2. ROR icon California Institute of Technology
  • 3. ROR icon Ontario Institute for Cancer Research
  • 4. ROR icon Wellcome Sanger Institute
  • 5. ROR icon Washington University in St. Louis

Abstract

WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and many aspects of fundamental biology. Throughout our 22-year history, we have continued to evolve to reflect progress and innovation in the science and technologies involved in the study of C. elegans. We strive to incorporate new data types and richer data sets, and to provide integrated displays and services that avail the knowledge generated by the published nematode genetics literature. Here, we provide a broad overview of the current state of WormBase in terms of data type, curation workflows, analysis, and tools, including exciting new advances for analysis of single-cell data, text mining and visualization, and the new community collaboration forum. Concurrently, we continue the integration and harmonization of infrastructure, processes, and tools with the Alliance of Genome Resources, of which WormBase is a founding member.

Additional Information

© The Author(s) 2022. Published by Oxford University Press on behalf of Genetics Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. The authors wish to thank the US National Human Genome Research Institute; UK Medical Research Council funding agencies for their ongoing support of WormBase and members of the C. elegans research community whose insights and explorations form the purpose of WormBase, all those contributing data through AFP or data submission forms, and all the WormBase users, for all your feedback, input and requests which inspire and guide us. Funding for WormBase is from US National Human Genome Research Institute [U24 HG002223]; UK Medical Research Council [MR/S000453/1]. Funding for open access charge: US National Human Genome Research Institute [U24 HG002223]. Conflicts of interest: None declared.

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Additional details

Identifiers

PMCID
PMC8982018
Eprint ID
113875
Resolver ID
CaltechAUTHORS:20220310-752284000

Funding

NIH
U24 HG002223
Medical Research Council (UK)
MR/S000453/1

Dates

Created
2022-03-15
Created from EPrint's datestamp field
Updated
2022-04-06
Created from EPrint's last_modified field

Caltech Custom Metadata

Caltech groups
WormBase , Division of Biology and Biological Engineering (BBE)