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Published June 15, 1992 | Version Published
Journal Article Open

Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA

Creators

  • 1. ROR icon California Institute of Technology

Abstract

Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.

Additional Information

© National Academy of Sciences. Contributed by John Abelson, February 26, 1992. We acknowledge with thanks the perceptive advice of Margaret Saks and Jeffrey Sampson in preparation of the manuscript. We also thank Haul Wong and David Teplow of the California Institute of Technology Microchemical Facility and Lynn Williams and Jolene Omiya of the University of Southern California Core Microchemical Laboratory for protein sequencing. This research was supported by grants from Office of Naval Research (N00014-86-K-0755) and National Institutes of Health (GM32637).

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Published - PNAS-1992-Normanly-5680-4.pdf

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PNAS-1992-Normanly-5680-4.pdf

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Additional details

Identifiers

PMCID
PMC49356
Eprint ID
52889
Resolver ID
CaltechAUTHORS:20141216-141202011

Funding

Office of Naval Research (ONR)
N00014-86-K-0755
NIH
GM32637

Dates

Created
2014-12-16
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Updated
2021-11-10
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