CaltechAUTHORS
Published August 15, 2007 | Version public
Journal Article Metadata-only

Aminopyrrolidineamide inhibitors of site-1 protease

Creators

  • 1. ROR icon Pfizer (United States)

Abstract

The discovery and efficacy of a series of potent aminopyrrolidineamide-based inhibitors of sterol regulatory element binding protein site-1 protease is described.

Additional Information

© 2007 Elsevier Ltd. Received 16 May 2007, Revised 4 June 2007, Accepted 5 June 2007, Available online 10 June 2007. The authors wish to thank Robert Corr, Neal Falcone, Anthony Provatas, Jack Oscarson, and the Pfizer Groton automated synthesis and registration laboratory for preparation of the initial S1P library and Kosea Frederick and Kazuko Sagawa for pharmacokinetic modeling of PF-429242 in rats.

Additional details

Identifiers

Eprint ID
103007
DOI
10.1016/j.bmcl.2007.06.031
Resolver ID
CaltechAUTHORS:20200505-150715952

Related works

Describes
10.1016/j.bmcl.2007.06.031 (DOI)

Dates

Created
2020-05-05
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Updated
2021-11-16
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