Published April 2012
| Version Supplemental Material
Journal Article
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Utilizing Terminal Oxidants to Achieve P450-Catalyzed Oxidation of Methane
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1.
California Institute of Technology
Abstract
Terminal oxidant-supported P450 reactions alleviate the need for substrate binding to initiate catalysis by chemically generating "compound I." This allows investigation of the innate substrate range of the enzyme active site. Using iodosylbenzene as the oxidant, CYP153A6, a medium-chain terminal alkane hydroxylase, exhibits methanol formation in the presence of methane demonstrating that P450-mediated methane hydroxylation is possible.
Additional Information
© 2012 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. Received: October 25, 2011; Published online: April 4, 2012. This work was supported by the Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Science, U.S. Department of Energy grant DE-FG02-06ER15762. We thank Dr. Nathan Dalleska for assistance with gas chromatography and Dr. Jared Lewis for helpful discussion.Attached Files
Supplemental Material - adsc_201100833_sm_miscellaneous_information.pdf
Files
adsc_201100833_sm_miscellaneous_information.pdf
Additional details
Identifiers
- Eprint ID
- 31599
- DOI
- 10.1002/adsc.201100833
- Resolver ID
- CaltechAUTHORS:20120522-134624475
Related works
- Describes
- 10.1002/adsc.201100833 (DOI)
Funding
- Department of Energy (DOE)
- DE-FG02-06ER15762
Dates
- Created
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2012-05-22Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field