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Published April 20, 2005 | Version Supplemental Material
Journal Article Open

The Direct Acyl-Alkylation of Arynes

Creators

  • 1. ROR icon California Institute of Technology

Abstract

An efficient and mild acyl-alkylation of arynes is described. The method is used to synthesize medium-sized carbocycles by the ring-expansion of cyclic β-ketoesters.

Additional Information

© 2005 American Chemical Society. Received 9 February 2005. Published online 26 March 2005. Published in print 1 April 2005. This work is dedicated to our friend and colleague Professor John D. Roberts, the father of benzyne.8 We are grateful to the NDSEG (predoctoral fellowship to U.K.T.), the A. P. Sloan Foundation, the Research Corporation, Pfizer, Novartis, Merck, Amgen, Lilly, Roche, Abbott, AstraZeneka, GlaxoSmithKline, and Caltech for financial support.

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Supplemental Material - ja050859msi20050306_053600.pdf

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Additional details

Identifiers

Eprint ID
74457
Resolver ID
CaltechAUTHORS:20170222-085357234

Funding

National Defense Science and Engineering Graduate (NDSEG) Fellowship
Alfred P. Sloan Foundation
Research Corporation
Pfizer
Novartis
Merck
Amgen
Lilly
Roche
Abbott
AstraZeneca
GlaxoSmithKline
Caltech

Dates

Created
2017-02-22
Created from EPrint's datestamp field
Updated
2021-11-11
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