The role of the redox active 4Fe–4S cluster of yeast Dna2

Dna2 is an essential nuclease-helicase conserved throughout eukaryotic organisms with an impressive repertoire of DNA maintenance activity (Budd & Campbell, 1995). Due to its major roles in Okazaki fragment processing during DNA replication, double strand break repair, telomere maintenance and mitochondrial DNA maintenance, it is not surprising that both Dna2 upregulation and mutation have been observed in various types of cancer (Lee, Kim, Yoo, & Lee, 2010; Strauss, 2014).