CaltechAUTHORS
Published October 2011 | Version Published
Journal Article Open

Functional photoacoustic microscopy of pH

Creators

  • 1. ROR icon Washington University in St. Louis

Abstract

pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.

Additional Information

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). Paper 11186LRR received Apr. 12, 2011; revised manuscript received Aug. 24, 2011; accepted for publication Sep. 9, 2011; published online Oct. 14, 2011. The authors thank James Ballard and Sandra Matteucci for help in manuscript edition. This work was supported in part by National Institutes of Health Grant Nos. U54CA136398 and R01 EB000712. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc, which, however, did not support this work.

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Additional details

Identifiers

PMCID
PMC3210191
Eprint ID
89749
Resolver ID
CaltechAUTHORS:20180918-140711597

Related works

Describes
http://resolver.caltech.edu/CaltechAUTHORS:20180918-140711236 (URL)

Funding

NIH
U54 CA136398
NIH
R01 EB000712

Dates

Created
2018-09-18
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Updated
2021-11-16
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