Published September 27, 2021
| Version Submitted + Supplemental Material
Discussion Paper
Open
How to model DNA replication in stochastic models of synthetic gene circuits (and why)
Creators
Abstract
Biocircuit modeling sometimes requires explicit tracking of a self-replicating DNA species. The most obvious, straightforward way to model a replicating DNA is structurally unstable and leads to pathological model behavior. We describe a simple, stable replication mechanism with good model behavior and show how to derive it from a mechanistic model of ColE1 replication.
Additional Information
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. This version posted September 27, 2021. The authors thank John Marken and Andrew Halleran for insightful discussions and thoughtful editing. The authors have declared no competing interest.Attached Files
Submitted - 2021.09.26.461880v1.full.pdf
Supplemental Material - media-1.zip
Files
2021.09.26.461880v1.full.pdf
Additional details
Identifiers
- Eprint ID
- 111092
- Resolver ID
- CaltechAUTHORS:20210929-174530596
Related works
- Describes
- https://github.com/sclamons/plasmid_replication_modeling (URL)
Dates
- Created
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2021-09-29Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field
Caltech Custom Metadata
- Caltech groups
- Division of Biology and Biological Engineering (BBE)