Use of right orbitofrontal repetitive transcranial magnetic stimulation (rTMS) augmentation for treatment-refractory obsessive-compulsive disorder with comorbid major depressive disorder
Creators
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1.
UCLA Health
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2.
California Institute of Technology
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3.
University of California, Los Angeles
Abstract
We examined the safety and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) of the right orbitofrontal cortex (OFC) in patients with refractory obsessive-compulsive disorder (OCD) and comorbid Major Depressive Disorder. All participants (n = 26) received excitatory stimulation of the left dorsolateral prefrontal cortex followed by inhibitory stimulation of bilateral supplementary motor area for 10 sessions. In 18 patients with poor early OCD response, treatment was augmented with OFC inhibitory stimulation after the tenth treatment session. Augmentation with OFC stimulation was well-tolerated, and associated with further alleviation of both OCD and depression symptoms, particularly in individuals with more severe illnesses.
Additional Information
RT research is supported by the National Institute of Mental Health (K23MH116117, R01MH121089) and the Brain & Behavior Research Foundation (NARSAD-27111). We thank the Ryan Family for their generous support of innovative approaches to depression treatment and groundbreaking TMS technology.Attached Files
Published - 1-s2.0-S0165178122004486-main.pdf
Files
1-s2.0-S0165178122004486-main.pdf
Additional details
Identifiers
- Eprint ID
- 117653
- Resolver ID
- CaltechAUTHORS:20221031-575177800.12
Funding
- National Institute of Mental Health
- K23MH116117
- National Institute of Mental Health
- R01MH121089
- Brain and Behavior Research Foundation
- NARSAD-27111
Dates
- Created
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2022-11-09Created from EPrint's datestamp field
- Updated
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2022-11-11Created from EPrint's last_modified field