Published November 1963 | Version Published
Journal Article Open

Chromosomally directed protein synthesis

Abstract

The different kinds of specialized cells of a higher organism differ among themselves in the kinds of enzymes and other proteins which they contain. Nonetheless, each possesses in the chromosomes of its nucleus the complete genomal DNA containing information concerning the manufacture of all of the kinds of enzymes contained in all of the kinds of cells of that creature. It is clear, therefore, that there is in the nucleus some mechanism for the control of genetic activity, a mechanism responsible for that orderly repression and derepression of gene activity which makes possible development. The present work concerns the control of genetic activity.

Additional Information

© 1963 by the National Academy of Sciences. Communicated September 30, 1963. We wish to acknowledge the fine technical assistance of Stella Tan, Ludia Brown, and Abbas Soleimani, as well as the continuing helpful counsel of Professor Paul O.P. Ts'o. Report of work supported by the U.S. Public Health Service, grants RG-3977, RG-5143, and A-3102.

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Identifiers

Eprint ID
11907
Resolver ID
CaltechAUTHORS:BONpnas63

Funding

Public Health Service
RG-3977
Public Health Service
RG-5143
Public Health Service
A-3102

Dates

Created
2008-10-12
Created from EPrint's datestamp field
Updated
2019-10-03
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