Published 2009
| Version Supplemental Material + Accepted Version
Journal Article
Open
Microfluidic confinement of single cells of bacteria in small volumes initiates high density behavior of quorum sensing and growth and reveals its variability
Abstract
One is a quorum: As few as one to three cells of Pseudomonas aeruginosa bacteria are confined in small volumes by the use of microfluidics. These small numbers of cells are able to activate quorum sensing (QS) pathways and achieve QS-dependent growth. The results also show that at low numbers of cells, initiation of QS is highly variable within a clonal population.
Additional Information
© 2009 WILEY-VCH. Issue published online: 22 JUL 2009. Article first published online: 29 JUN 2009. Manuscript Received: 21 MAR 2009. This research was supported by the NIH Director's Pioneer Award DP1 OD003584 to R.F.I. We thank S. Molin for generously providing the reporter strain, J. Shapiro and O. Zaborina for helpful discussion, and E. B. Haney for contributions to writing this manuscript.Attached Files
Accepted Version - nihms132881.pdf
Supplemental Material - Ismagilov_Angew_Chem_2009_QS_48_5908_5911_JQB_MB_Supp_Info.pdf
Files
Ismagilov_Angew_Chem_2009_QS_48_5908_5911_JQB_MB_Supp_Info.pdf
Additional details
Identifiers
- PMCID
- PMC2748941
- Eprint ID
- 40779
- DOI
- 10.1002/anie.200901550
- Resolver ID
- CaltechAUTHORS:20130821-160716355
Funding
- NIH
- 1DP1 OD003584
Dates
- Created
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2013-08-26Created from EPrint's datestamp field
- Updated
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2023-10-24Created from EPrint's last_modified field