Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes
Creators
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1.
Washington University in St. Louis
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2.
Philips (United States)
Abstract
By modifying a clinical ultrasound array system, we develop a novel handheld photoacoustic probe for image-guided needle biopsy. The integration of optical fiber bundles for pulsed laser light delivery enables photoacoustic image-guided insertion of a needle into rat axillary lymph nodes with accumulated indocyanine green (ICG). Strong photoacoustic contrast of the needle is achieved. After subcutaneous injection of the dye in the left forepaw, sentinel lymph nodes are easily detected, in vivo and in real time, beneath 2-cm 2-cm-thick chicken breast overlaying the axillary region. ICG uptake in axillary lymph nodes is confirmed with fluorescence imaging both in vivo and ex vivo. These results demonstrate the clinical potential of this handheld photoacoustic system for facile identification and needle biopsy of sentinel lymph nodes for cancer staging and metastasis detection in humans.
Additional Information
© 2010 SPIE. Paper 10162R received Mar. 26, 2010; revised manuscript received May 25, 2010; accepted for publication May 28, 2010; published online Aug. 16, 2010. This work was supported in part by grants from the National Institutes of Health (Grants R01 EB000712, R01 EB008085, and U54 CA136398—the Network for Translational Research). L.V.W. has a financial interest in Microphotoacoustics, Inc., and in Endra, Inc., which, however, did not support this work. T.N.E, L.J., and M.D.P are employees of Philips Research.Attached Files
Published - 046010_1.pdf
Files
046010_1.pdf
Additional details
Identifiers
- PMCID
- PMC2937045
- Eprint ID
- 70020
- Resolver ID
- CaltechAUTHORS:20160830-091304188
Funding
- NIH
- R01 EB000712
- NIH
- R01 EB008085
- NIH
- U54 CA136398
Dates
- Created
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2016-08-31Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field