CaltechAUTHORS
Published June 3, 2015 | Version Accepted Version + Supplemental Material
Journal Article Open

Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters

Creators

  • 1. ROR icon California Institute of Technology

Abstract

An improved method for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex.

Additional Information

© 2014 Elsevier B.V. Received 30 September 2014; Received in revised form 24 October 2014; accepted 27 October 2014. The authors wish to thank NIH-NIGMS (R01GM080269-01), Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support. S.-J.H thanks Fulbright Commission (Foreign Student Program, No. 15111120) and the Ilju Foundation of Education & Culture (Pre-doctoral Research Fellowship) for financial support. Catalyst center (Caltech) is acknowledged for assistance with reaction screenings. Drs. Florian Vogt, Sandy Ma, Xiaoquing Han, and Shyam Krishnan are acknowledged for preliminary research.

Attached Files

Accepted Version - nihms-638763.pdf

Supplemental Material - mmc1.pdf

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Additional details

Identifiers

PMCID
PMC4429905
Eprint ID
51486
DOI
10.1016/j.tet.2014.10.065
Resolver ID
CaltechAUTHORS:20141110-091731285

Related works

Describes
10.1016/j.tet.2014.10.065 (DOI)

Funding

NIH
R01GM080269-01
Amgen
Gordon and Betty Moore Foundation
Caltech
Fulbright Commission
15111120
Ilju Foundation of Education & Culture

Dates

Created
2014-11-10
Created from EPrint's datestamp field
Updated
2021-11-10
Created from EPrint's last_modified field