CaltechAUTHORS
Published June 1, 2018 | Version Accepted Version
Journal Article Open

Enantioselective palladium-catalyzed allylic alkylation reactions in the synthesis of Aspidosperma and structurally related monoterpene indole alkaloids

Creators

  • 1. ROR icon Division of Chemistry
  • 2. ROR icon California Institute of Technology

Abstract

Enantioselective Pd-catalyzed allylic alkylations of prochiral enolates represent a powerful tool for the construction of all-carbon quaternary stereocenters. This review describes the emergence of such reactions as strategic linchpins that enable efficient, stereocontrolled syntheses of Aspidosperma and related monoterpene indole alkaloids.

Additional Information

© 2018 The Royal Society of Chemistry. The article was received on 23 Dec 2017 and first published on 16 Apr 2018. The authors wish to thank NIH-NIGMS (R01GM080269), Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support. B. P. P. thanks the NSF for a predoctoral fellowship (Grant DGE-1144469). Dr Robert Allen Craig, II, is thanked for editorial assistance. The authors declare no conflicts of interest.

Attached Files

Accepted Version - nihms961707.pdf

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Additional details

Identifiers

PMCID
PMC6013405
Eprint ID
85877
DOI
10.1039/c7np00069c
Resolver ID
CaltechAUTHORS:20180416-135313177

Related works

Describes
10.1039/c7np00069c (DOI)

Funding

NIH
R01GM080269
Amgen
Gordon and Betty Moore Foundation
Caltech
NSF Graduate Research Fellowship
DGE-1144469

Dates

Created
2018-04-16
Created from EPrint's datestamp field
Updated
2022-03-09
Created from EPrint's last_modified field