Published December 7, 2010
| Version Accepted Version
Journal Article
Open
Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains
Abstract
Protein-based biomaterials that promote rapid wound healing are prepared by expression of artificial genes in bacterial cells. Artificial extracellular matrix proteins containing full-length fibronectin domains 9 and 10 exhibit strong α_5β_1 integrin binding and support rapid spreading, proliferation, and collective migration of fibroblasts.
Additional Information
© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: July 7, 2010; Revised: August 11, 2010; Published online: September 30, 2010. The authors thank Drs. Stacey Maskarinec and Shelly Tzlil for discussions. We acknowledge Dr. Anand Asthagiri for Rat-1 fibroblasts and generous access to the fluorescence microscope. E. F. is supported in part by the Nanyang Overseas Scholarship, Singapore. This work is supported by NIH EB001971, by the NSF Center for Science and Engineering of Materials, and by the Armed Forces Institute for Regenerative Medicine Wake Forest–Pittsburgh Consortium.Attached Files
Accepted Version - nihms262413.pdf
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nihms262413.pdf
Additional details
Identifiers
- PMCID
- PMC3027490
- Eprint ID
- 21961
- Resolver ID
- CaltechAUTHORS:20110202-085127824
Funding
- Nanyang Overseas Scholarship
- NIH
- EB001971
- NSF
- Armed Forces Institute for Regenerative Medicine Wake Forest-Pittsburgh Consortium
Dates
- Created
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2011-02-14Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field