Signal-Sensitive Release of Contents from Liposomes Bearing Surface-Grafted Polyelectrolyte Chains

Therapeutic advantages of signal-sensitive drug delivery are easily imagined. Current dosage methods are most often empirically based, and only rarely reflect the actual time dependence of the patient's therapeutic need. In principle, self-regulated delivery systems would reduce the administered dose to a minimum while maintaining a therapeutically effective concentration of the agent at the target site. In practice, the routine application of self-regulated delivery systems remains relatively remote.