A molecular map of the immune response region from the major histocompatibility complex of the mouse
Creators
-
1.
California Institute of Technology
Abstract
A stretch of 200 kilobases (kb) of DNA from the I region of the mouse major histocompatibility complex has been cloned and characterized. It contains the genes for the biochemically defined class II proteins Eα, Eβ and Aβ. DNA blot analyses suggest that the I region may contain only 6–8 class II genes. Correlation of our molecular map with the genetic map of the I region confines two of the five I subregions, I–J and I–B, to less than 3.4 kb of DNA at the 3′ end of the Eβ gene where a hotspot for recombination has been observed. Indeed, the I–A and I–E subregions may be contiguous. If so, the I–B and I–J subregions are not encoded in the I region between the I–A and I–E subregions.
Copyright and License
Copyright © 1982, Springer Nature Limited
Acknowledgement
We thank Elizabeth Gibb for technical assistance, Joan Kobori for a gift of probe 3, Bernita Larsh for the preparation of the manuscript, and all members of the Hood group for stimulating discussions. We also thank P. Singer and J. Klein, D. Murphy and C. David for various congeneic mouse strains. M.S. was supported by the Deutsche Forschungsgemeinschaft and by a Senior Lievre Fellowship from the California Division of the American Cancer Society (S-48-82). J.M. is a postdoctoral fellow of the Arthritis Foundation. J.F. is the recipient of an American Cancer Society Faculty Research Award. The work was supported by grants from the NIH.
Errata
In the version of this article initially published, the surname of Jeffrey Frelinger was misspelled (Srelinger). This notice serves to update the record.
Additional details
Related works
- Describes
- Journal Article: https://rdcu.be/dU7CE (URL)
- Is corrected by
- Erratum: 10.1038/s41586-023-06940-6 (DOI)
Funding
- Deutsche Forschungsgemeinschaft
- American Cancer Society
- Senior Lievre Fellowship S-48-82
- Arthritis Foundation
- National Institutes of Health
Dates
- Accepted
-
1982-09-23Accepted
- Updated
-
2024-05-23Correction
Caltech Custom Metadata
- Publication Status
- Published