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Published March 20, 2008 | Version Supplemental Material + Accepted Version
Journal Article Open

Homogeneous Pd-Catalyzed Enantioselective Decarboxylative Protonation

Creators

  • 1. ROR icon California Institute of Technology

Abstract

General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the α-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl β-ketoester starting materials.

Additional Information

© 2008 American Chemical Society. Received November 21, 2007. Publication Date (Web): February 28, 2008. We thank Sankyo Co., Ltd. (financial support of T.N.), Eli Lilly (predoctoral fellowship to J.T.M.), Amgen, and Bristol-Myers Squibb for generous funding.

Attached Files

Accepted Version - nihms243551.pdf

Supplemental Material - ol702821j-file003.pdf

Files

nihms243551.pdf

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Additional details

Identifiers

PMCID
PMC2966305
Eprint ID
74444
Resolver ID
CaltechAUTHORS:20170221-162726154

Funding

Sankyo Co., Ltd.
Eli Lilly
Amgen
Bristol-Myers Squibb

Dates

Created
2017-02-22
Created from EPrint's datestamp field
Updated
2021-11-11
Created from EPrint's last_modified field